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We reviewed the outcome of patients with adrenocortical carcinoma who had undergone radical surgery at tertiary referral centers in Italy from 1985 through 2003. During this period, adjuvant mitotane treatment was routinely used in some centers but not in others, providing an opportunity to compare two contemporary groups of patients. To control further for potential biases, we included a second independent control group for comparison with mitotane-treated patients in our analysis, a cohort of German patients who were treated with surgery only. The primary aim of the study was to evaluate the efficacy of adjuvant mitotane in prolonging recurrence-free survival; secondary aims were assessments of overall survival and adverse events. Italian Patients. We performed a retrospective analysis among patients with adrenocortical carcinoma who had undergone radical surgery between January 1985 and December 2003 at eight tertiary referral centers in Italy.

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